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ARCHIPELAGO

Effect of irbesartan and enalapril in non-ST segment elevation acute coronary syndrome

Terminée

Remerciements de la Famille COLLET

Prix de Recherche Pr Jean-Philippe COLLET

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objectif

International multicentric trial aiming to compare, over 2 months, the effect of a treatment with irbesartan to a treatment with enalapril on cardio-vascular markers in patients with acute coronary syndrome without ST segment elevation.

date de réalisation

2006

nombre de patients

429

nombre de centres participants

63 centers in 11 countries

type de financement

Private (Sanofi-Aventis et BMS)

Référence

NCT00296218

Randomized Comparison of a Two-month Regimen of Irbesartan Versus Enalapril on Cardiovascular Markers in Patients With Acute Coronary Syndrome Without ST Segment Elevation (ARCHIPELAGO)

Study Description

The main objective of this study is to assess if a two-month regimen of irbesartan in patients hospitalized for acute coronary syndrome without ST segment elevation can reduce inflammation markers (ie hsCRP), in comparison to a similar regimen of enalapril.

source clinicaltrials.gov

Publications

Effect of irbesartan and enalapril in non-ST elevation acute coronary syndrome: results of the randomized, double-blind ARCHIPELAGO study
Gilles Montalescot, Helmut Drexler, Richard Gallo, Thomas Pearson, Martin Thoenes, Deepak L Bhatt
Publicated in European Heart Journal
Usefulness of biomarker strategy to improve GRACE score's prediction performance in patients with non-ST-segment elevation acute coronary syndrome and low event rates
Farzin Beygui, Johanne Silvain, Ana Pena, Anne Bellemain-Appaix, Jean-Philippe Collet, Helmut Drexler, Deepak Bhatt, Eric Vicaut, Gilles Montalescot
Publicated in The American Journal of Cardiology

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