A Comparison of Prasugrel at the Time of Percutaneous Coronary Intervention (PCI) Or as Pretreatment At the Time of Diagnosis in Patients With Non-ST-Elevation Myocardial Infarction (NSTEMI) : The ACCOAST Study
Study Description
This trial consists of two arms. One arm is a non pre-treatment arm. Participants in this arm will receive placebo immediately after NSTEMI diagnosis and prior to the diagnostic coronary angiography. A 60 mg prasugrel loading dose will be given immediately after coronary angiography when proceeding to PCI. Subsequently, participants will receive daily maintenance doses of prasugrel until day 30. Participants who are greater than or equal to 75 years of age or who have a body weight less than 60 kilograms (kg) will receive 5 mg oral dose daily. All others will receive a 10 mg oral daily maintenance dose for 30 days.
The other arm is a pre-treatment arm where participants will receive a split loading dose regimen with 30 mg of prasugrel administered immediately after NSTEMI diagnosis and prior to diagnostic coronary angiography. The remainder of the loading dose (30 mg) will be administered when the participants are proceeding to PCI. Subsequently, participants will receive daily maintenance doses of prasugrel until day 30. Participants who are greater than or equal to 75 years of age or who have a body weight less than 60 kg will receive 5 mg oral dose daily. All others will receive a 10 mg oral daily maintenance dose for 30 days.
source clinicaltrials.gov
Publications
- Interval From Initiation of Prasugrel to Coronary Angiography in Patients With Non-ST-Segment Elevation Myocardial Infarction
Johanne Silvain, Tomasz Rakowski, Benoit Lattuca, Zhenyu Liu, Leonardo Bolognese, Patrick Goldstein, Christian Hamm, Jean-Francois Tanguay, Jur Ten Berg, Petr Widimsky, Debra Miller, Jean-Jacques Portal, Jean-Philippe Collet, Eric Vicaut, Gilles Montalescot, Dariusz Dudek, ACCOAST Investigators
Publicated in Journal of the American College of Cardiology - Optimal timing of initiation of oral P2Y12-receptor antagonist therapy in patients with non-ST elevation acute coronary syndromes. Lessons learnt from the ACCOAST-trial
Uwe Zeymer, Gilles Montalescot, Diego Ardissino, Leonardo Bolognese, Peter Clemmensen, Jean-Philippe Collet, Jose Lopez-Sendon, Petr Widimsky
Publicated in European Heart Journal, Acute Cardiovascular Care - Impact of Access Site on Bleeding and Ischemic Events in Patients With Non-ST-Segment Elevation Myocardial Infarction Treated With Prasugrel : The ACCOAST Access Substudy
Italo Porto, Leonardo Bolognese, Dariusz Dudek, Patrick Goldstein, Christian Hamm, Jean-François Tanguay, Jurrien Ten Berg, Petr Widimský, Nicolas Le Gall, Anthony J Zagar, LeRoy A LeNarz, Debra Miller, Gilles Montalescot, ACCOAST Investigators
Publicated in JACC: Cardiovascular Interventions - Impact of prasugrel pretreatment and timing of coronary artery bypass grafting on clinical outcomes of patients with non-ST-segment elevation myocardial infarction : From the A Comparison of Prasugrel at PCI or Time of Diagnosis of Non-ST-Elevation Myocardial Infarction (ACCOAST) study
Dariusz Dudek, Artur Dziewierz, Petr Widimsky, Leonardo Bolognese, Patrick Goldstein, Christian Hamm, Jean-Francois Tanguay, LeRoy LeNarz, Debra L Miller, Eileen Brown, Jurrien Ten Berg, Gilles Montalescot, ACCOAST Investigators
Publicated in American Heart Journal - Effect of prasugrel pre-treatment strategy in patients undergoing percutaneous coronary intervention for NSTEMI : the ACCOAST-PCI study
Gilles Montalescot, Jean-Philippe Collet, Patrick Ecollan, Leonardo Bolognese, Jurrien Ten Berg, Dariusz Dudek, Christian Hamm, Petr Widimsky, Jean-François Tanguay, Patrick Goldstein, Eileen Brown, Debra L Miller, LeRoy LeNarz, Eric Vicaut, ACCOAST Investigators
Publicated in Journal of the American College of Cardiology - Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes
Gilles Montalescot, Leonardo Bolognese, Dariusz Dudek, Patrick Goldstein, Christian Hamm, Jean-Francois Tanguay, Jurrien M ten Berg, Debra L Miller, Timothy M Costigan, Jochen Goedicke, Johanne Silvain, Paolo Angioli, Jacek Legutko, Margit Niethammer, Zuzana Motovska, Joseph A Jakubowski, Guillaume Cayla, Luigi Oltrona Visconti, Eric Vicaut, Petr Widimsky, ACCOAST Investigators
Publicated in The New England Journal of Medecine - A comparison of prasugrel at the time of percutaneous coronary intervention or as pretreatment at the time of diagnosis in patients with non-ST-segment elevation myocardial infarction : design and rationale for the ACCOAST study
Gilles Montalescot, Leonardo Bolognese, Dariusz Dudek, Patrick Goldstein, Christian Hamm, Jean-Francois Tanguay, Jur ten Berg, Petr Widimsky, Junxiang Luo, Debra L Miller, Jochen Goedicke
Publicated in American Heart Journal
